Asha's Focus: Devasting Neurological Conditions
We levarage our expertise in computational and medicinal chemistry paired with validated biological drivers of disease to design novel compounds for disease with high unmet medical need. Our mission is to eliminate neurological disease.
A Central Contributor to Neurological Pathologies
Maintaining the health and efficiency of the mitochondrial network is of vital importance to cellular health and function. Beyond its role in energy production, the mitochondrial network is a critical signaling hub that greatly influences how the cell responds to harmful stimuli, regardless of what triggers the original pathological change. One method of signaling is to dynamically fragment or fuse the network to signal global changes in the cell.
Hyperfragmentation has been found to be a key contributor to neurological disease pathology and progression and is a pathogenic feature in diseases including Parkinson's Disease, Alzheimer's Disease, Stroke, and others.